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Rock Formations on the Beach

Publications

    George, Dare; Tepe, Jetze J. Total Synthesis of Nagelamide W. Journal of Organic Chemistry, 2023, 88, 13, 9306–9312.
    https://doi.org/10.1021/acs.joc.3c00867
    Savelson, Evan; Tepe, Jetze J. Accessing Highly Oxidized Imidazolidinone Cores via a Curtius Rearrangement: Total Synthesis of Colensolide A. Organic Letters 2023, 25, 3698–3701. https://doi.org/10.1021/acs.orglett.3c01139
    Staerz, Sophia S.; Lisabeth, Erika M.; Njomen, Evert; Dexheimer, Thomas S.; Neubig, Richard R.; Tepe, Jetze J. Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators. ACS Omega, 2023, 8, 15650–15659. https://doi.org/10.1021/acsomega.3c01158
    Vanecek, Allison, S.; Mojsilovic-Petrovic, Jelena; Kalb, Robert, G.; Tepe, Jetze J. Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection, ACS Chemical Neuroscience 2023, 14, 1439–1448. https://doi.org/10.1021/acschemneuro.2c00732
    Mehedi, Md Shafaat Al; George, Dare E.; Tepe, Jetze J. Sc(OTf)3 mediated one-pot synthesis of 3,4-disubstituted 1H-pyrazoles and 3,5-disubstituted pyridines from hydrazine or ammonia with epoxides. Journal of Organic Chemistry, 2022, 87, 24, 16820–16828. https://doi.org/10.1021/acs.joc.2c02544
    Hou, Zhilin, Vanecek, Allision, S.; Tepe, Jetze, J.: Odom, Aaron L., Synthesis, Structure, Properties, and Cytotoxicity of a (Quinoline)RuCp+ Complex, Dalton Transactions, 2023, 52, 721-730. https://pubs.rsc.org/en/content/articlepdf/2023/dt/d2dt03484k
    Hubbell, Grace E.; Tepe, Jetze J. Rh(III)-catalyzed C-H activation/annulation of benzo- hydroxamates and 2-imidazolones: access to urea-fused-dihydroisoquinolone scaffolds reminiscent of pyrrole-alkaloid natural products, Organic Letters, 2022, 24, 6740–6744. https://doi.org/10.1021/acs.orglett.2c02508
    Staerz, S. D.; Jones, C. L. and Tepe, Jetze J. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. Journal of Medicinal Chemistry, 2022, 65, 6631–6642. https://doi.org/10.1021/acs.jmedchem.1c02158
    Njomen, Evert; Vanecek, Allison; Lansdell, Theresa A.; Bernard, Matt P.; Yang, Ya-Ting; Schall, Peter Z.; Isaac, Daniel; Omar Alkharabsheh; Al-Janadi Anas; Giletto, Matthew B.; Ellsworth, Edmund; Taylor, Catherine; Tang, Terence; Lau, Sarah; Bailie, Marc, Bernard; Jamie J.; Yuzbasiyan-Gurkan, Vilma and Tepe, Jetze J., Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma, Biomedicines 2022, 10, 938. https://www.mdpi.com/2227-9059/10/5/938
    Savelson, Evan; Tepe, Jetze J. One-Pot Friedel−Crafts/Robinson−Gabriel Synthesis of the Indole-Oxazole Scaffold and its Application to the Synthesis of Breitfussins C, G, and H, Journal of Organic Chemistry, 2022, 88, 755–761. https://doi.org/10.1021/acs.joc.2c00033
    George, D. E. and Tepe, Jetze J. Advanced in Proteasome Enhancement by Small Molecules. Biomolecules, 2021, 11, 1789. https://www.mdpi.com/2218-273X/11/12/1789
    Gao, Kaifu; Wang, Rui; Chen, Jiahui; Tepe, Jetze J.; Huang, Faqing; and Wei, Guo-Wei. Perspectives on SARS-CoV-2 Main Protease Inhibitors. Journal of Medicinal Chemistry, 2021, 64, 16922–16955. https://doi.org/10.1021/acs.jmedchem.1c00409
    Keel, Katarina L.; and Tepe, Jetze J. Total Synthesis of Nortopsentin D via a Late-Stage Pinacol-like Rearrangement, Organic Letters, 2021, 23, 5368-5372. https://doi.org/10.1021/acs.orglett.1c01681
    Fiolek, Taylor J.; Keel, Katarina L. and Tepe, Jetze J. Fluspirilene analogs activate the 20S proteasome and overcome proteasome impairment by intrinsically disorder protein oligomers, ACS Chemical Neuroscience 2021, 12, 1438–1448. https://doi.org/10.1021/acschemneuro.1c00099
    Fiolek, Taylor J.; Magyar, Christina L.; Wall, Tyler J.; Davies, Steven B.; Campbell, Molly V.; Savich Christopher J.; Tepe, Jetze J. and Mosey, R. Adam, Dihydroquinazolines enhance 20S proteasome activity and induce degradation of alpha-synuclein, an intrinsically disordered protein associated with neurodegeneration, Bioorganic and Medicinal Chemistry Letters, 2021, 36, 127821. https://par.nsf.gov/servlets/purl/10213946
    Hubbell, Grace E. and Tepe, Jetze J. Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors, RCS Chemical Biology 2020, 1, 305-332. https://pubs.rsc.org/en/content/articlelanding/2020/cb/d0cb00111b
    Keel, Katarina L. and Tepe, Jetze J. The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products, Organic Chemistry Frontiers 2020, 7, 3284 – 3311. https://doi.org/10.1039/D0QO00764A
    Njomen, Evert; Lansdell, Theresa A.; Benham, Vanessa; Bernard, Matt P.; Yang, Ya-Ting; Schall, Peter Z.; Isaac, Daniel; Omar Alkharabsheh; Al-Janadi Anas; Giletto, Matthew B.; Ellsworth, Edmund; Taylor, Catherine; Tang, Terence; Lau, Sarah; Bailie, Marc, Bernard; Jamie J.; Yuzbasiyan-Gurkan, Vilma and Tepe, Jetze J., 20S proteasome enhancement targets c-MYC and induces in vivo anti-tumor efficacy, BioRxiv, 2020. https://doi.org/10.1101/2020.08.24.265470
    Mehedi, Md Shafaat Al and Tepe, Jetze J. Recent Advances in the Synthesis of Imidazolines (2009-2020), Adv. Synth. Catal. 2020, 362, 4189-4225. https://doi.org/10.1002/adsc.202000709
    Mehedi, Md Shafaat Al and Tepe, Jetze J. Sc(OTf)3 Mediated One-Pot Synthesis of 2,3-Disubstituted Quinolines from Anilines and Epoxides, Journal of Organic Chemistry, 2020, 85, 10, 6741–6746. https://doi.org/10.1021/acs.joc.0c00803
    Jones, Corey and Tepe, Jetze, Proteasome Activation to Combat Proteotoxicity, Molecules, 2019, 24, 2841. PMID 31387243 https://doi.org/10.3390/molecules24152841
    Njomen, Evert and Tepe, Jetze, Regulation of Autophagic Flux by the 20S proteasome. Cell, Chemical Biology, 2019, 26., 1283-1294. PMID31327703 https://doi.org/10.1016/j.chembiol.2019.07.002
    Mehedi, Md Shafaat Al and Tepe, Jetze J. Diastereoselective one-pot synthesis of oxazolines using sulfur ylides and acyl imines, Journal of Organic Chemistry, 2019, 84, 7219-7226. PMID31117573 https://doi.org/10.1021/acs.joc.9b00883
    Njomen, Evert and Tepe, Jetze J. Proteasome activation as a new therapeutic approach to target proteotoxic disorders, Journal of Medicinal Chemistry, 2019, 62, 6469-6481. PMID30839208 https://doi.org/10.1021/acs.jmedchem.9b00101
    Giletto, Matthew B; Osmulski, Pawel A.; Jones, Corey L.; Gaczynska Marie E. and Tepe, Jetze J. Pipecolic esters as new templates for proteasome inhibition, Organic & Biomolecular Chemistry, 2019, 17, 2734-2746. PMID 307784535 https://doi.org/10.1039/C9OB00122K
    Jones, Corey L.; Njomen, Evert; Sjogren B.; Dexheimer, Thomas S. and Tepe, Jetze J. Small molecule enhancement of 20S proteasome activity targets intrinsically disordered proteins. ACS Chemical Biology 2017, 15;12(9):2240-2247. PMID: 28719185. https://doi.org/10.1021/acschembio.7b00489
    Gao, Shuang, Bethel, Travis K. Kakeshpour T.; Hubbell, Grace E., Jackson, James, E. and Tepe, Jetze J. Substrate Controlled Regioselective Bromination of 2-Aycl Pyrroles Using Tetrabutyl Ammonium Tribromide (TBABr3), Journal of Organic Chemistry, 2018, 83, 9250-9255. PMID: 29969032 https://doi.org/10.1021/acs.joc.8b01251
    Njomen, Evert; Osmulski, Pawel A.; Jones, Corey L; Lansdell, Theresa A. Gaczynska, Maria E. and Tepe, Jetze J. Small Molecule Modulation of Proteasome Assembly, ACS Biochemistry, 2018, 57,4214-4224. PMID: 29897236 https://doi.org/10.1021/acs.biochem.8b00579
    McDaniel, Tanner J.; Lansdell, Thereasa A.; Dissanayake, Amila A.; Azevedo, Lauren M.; Claes, Jacob; Odom, Aaron L. and Tepe, Jetze J. Substituted quinolines as noncovalent proteasome inhibitors, Bioorganic and Medicinal Chemistry, 2016, 24, 2441-2450. PMID: 27112450. https://doi.org/10.1016/j.bmc.2016.04.005
    Kuszpit, Michael R.; Giletto, Matthew B.; Jones, Corey L.; Bethel, Travis K. and Tepe, Jetze J. Hydroxyamination of olefins using Br-N-(CO2Me)2. Journal of Organic Chemistry, 2015, 80, 1440-1445. PMID: 25574949 https://doi.org/10.1021/jo502369d
    Beck, Philipp; Lansdell, Theresa A.; Hewlett, Nicole M.; Tepe, Jetze J. and Groll, Michael, Indolo-phakellins as 5-specific noncovalent proteasome inhibitors, Angewandte Chemie Int. Ed. 2015, 54, 2830-2833. PMID: 25581903. https://doi.org/10.1002/anie.201410168
    Basson, Marc D.; Zeng B; Downey C; Siriveluprabhakara S, Tepe, Jetze J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-. Molecular Oncology, 2015, 9, 513-526. PMC4487881 https://doi.org/10.1016/j.molonc.2014.10.008
    Hewlett, Nicole M. and Tepe, Jetze J. 2-Phenyl oxazolone. Electronic Encyclopedia of Reagents for Organic Synthesis, 2014, 1-3. https://doi.org/10.1002/047084289X.rn01743
    Zaib, Rahman S. and Tepe, Jetze J. A concise total synthesis of hymenialdisine, Tetrahedron Letters, 2015, 56, 3011-3013. https://doi.org/10.1016/j.tetlet.2014.10.022
    Azevedo, Lauren M.; Lansdell, Theresa A.; Ludwig, Jacob R.; Mosey, R. Adam; Woloch, Daljinder K.; Cogan, Dillon P.; Patten, Gregory P.; Kuszpit, Michael R.; Fisk, Jason S. and Tepe, Jetze J. Inhibition of the human proteasome by imidazoline scaffolds. Journal of Medicinal Chemistry, 2013, 56, 5974-5978. PMC3844044 https://doi.org/10.1021/jm400235r
    Lansdell, Theresa A.; Hurchla, Michelle A.; Xiang, J.; Hovde, S.; Weilbaecher, Katherine N.; Henry, R. William; Tepe, Jetze J. Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo. ACS Chemical Biology, 2013, 8, 578-587. PMC3600058 https://doi.org/10.1021/cb300568r
    Lansdell, Theresa A.; Hewlett, Nicole M.; Skoumbourdis, Amanda P.; Fodor, Matthew D.; Seiple, Ian B.; Su, Shun; Baran, Phil. S.; Feldman, Ken S.; Tepe, Jetze J. Palau’amine and Related Oroidin-alkaloids Dibromophakellin and Dibromophakellstatin Inhibit the Human 20S Proteasome. Journal of Natural Products, 2012, 75, 980-985. PMC3367325 https://doi.org/10.1021/np300231f
    Lansdell, Theresa A.; O'Reilly, Sandra; Woolliscroft, Tracey; Azevedo, Lauren M.; Kahlon, Daljinder K.; Hovde, Stacy; McCormick, J. Justin; Henry, R. William; Cornicelli, Joseph A.; Tepe, Jetze J. Non-competitive inhibition of the human proteasome attenuates collagen-induced arthritis. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 4816-4819. PMID: 22682057 https://doi.org/10.1016/j.bmcl.2012.05.056
    Saleem, Rahman Shah Zaib; Lansdell, Theresa A.; Tepe, Jetze J. Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors. Bioorganic & Medicinal Chemistry 2012, 20, 1475-1481. PMID: 20481587 https://doi.org/10.1016/j.bmc.2011.12.054
    Nguyen, Thu N.T.; Saleem, Rahman S. Z.; Luderer, Micah, J.; Tepe, Jetze J. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chemical Biology, 2012, 7, 172-184. PMID: 22004065 https://doi.org/10.1021/cb200320c
    Nguyen, T. N. T.; Tepe, J. J, Checkpoint kinase inhibitors. Current Medicinal Chemistry, 2011, 18, 4368-4374. https://pubmed.ncbi.nlm.nih.gov/21861812/
    Hewlett, Nicole M.; Tepe, Jetze J. Total synthesis of the natural product ()-dibromophakellin and analogues. Organic Letters, 2011, 13, 4550-4553. PMC3162990 https://doi.org/10.1021/ol201741r
    Qu, Ke; Fisk, Jason S.; Tepe, Jetze J. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines. Tetrahedron Letters, 2011, 52, 4840-4842. PMC3157035 https://doi.org/10.1016/j.tetlet.2011.07.022
    Kuszpit, Michael R.; Wulff, William D.; Tepe, Jetze J. One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines. Journal of Organic Chemistry, 2011, 76, 2913-2919. PMC3074022 https://doi.org/10.1021/jo200101q
    Frawley Cass, Samantha M.; Tepe, Jetze J. Identification of phosphoproteins and their impact as biomarkers in cancer therapeutics. Current Signal Transduction Therapy, 2011, 6, 113-140. https://doi.org/10.2174/157436211794109389
    Saleem, Rahman Shah Zaib; Tepe, Jetze J., Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones. Journal of Organic Chemistry, 2010, 75, 4330-4332. https://doi.org/10.1021/jo100716m
    Wang, Wei-Han; Palumbo, Amanda M.; Tan, Yu-Jing; Reid, Gavin E.; Tepe, Jetze J.; Bruening, Merlin L., Identification of p65-Associated Phosphoproteins by Mass Spectrometry after On-Plate Phosphopeptide Enrichment Using Polymer-oxotitanium Films. Journal of Proteomic Research, 2010, 9, 3005-3015. https://doi.org/10.1021/pr901200m
    Tepe, Jetze J., Recent advances in cycloaddition reactions in natural product synthesis. Current Organic Synthesis, 2010,7, 311.
    Hewlett, N. M.; Hupp, C. D.; Tepe, J. J., Reactivity of oxazol-5-(4H)-ones and their application toward natural product synthesis. Synthesis, 2009, 17, 2825-2839. https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0029-1216924
    Frawley Cass, Samantha M.; Reid, Gavin E.; Tepe, Jetze J., Synthesis of diazo ketone solid supports and their application towards the enrichment of phosphorylated peptides. Organic and Biomolecular Chemistry, 2009, 7, 3291-3299. https://pubs.rsc.org/en/content/articlelanding/2009/OB/b906577f
    Hupp, Christopher D.; Tepe, Jetze J. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride-Mediated Oxazole Rearrangement: Gaining Access to a Unique Marine Alkaloid Scaffold. Journal of Organic Chemistry, 2009, 74, 3406-3413 https://doi.org/10.1021/jo900264p
    Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Hupp, Christopher D.; Friebe, Timothy L.; Hovde, Stacy; Jones, A. Daniel; Dyer, Richard D.; Henry, R. William; Tepe, Jetze J., Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds. Journal of Medicinal Chemistry, 2009, 52, 1302-1309. https://doi.org/10.1021/jm8013162
    Tepe, Jetze J., Natural Product Inspired Small Molecular Scaffolds in Anticancer Therapy. Current Bioactive Compounds, 2009, 5, 1. https://www.eurekaselect.com/article/13873
    Mosey, Robert A.; Tepe, Jetze J., New Synthetic Route to Access (±) Salinosporamide A via an Oxazolone Mediated Ene-type reaction. Tetrahedron Letters 2009, 50, 295-297. https://doi.org/10.1016/j.tetlet.2008.10.154
    Nguyen, T. N. T.; Tepe, J. J., Preparation of hymenialdisine, analogs and their evaluation as kinase inhibitors. Current Medicinal Chemistry, 2009, 16, 3122-3143. https://www.eurekaselect.com/article/14594
    Kahlon, Daljinder K.; Lansdell, Theresa A.; Fisk, Jason S.; Tepe, Jetze J., Structural activity relationship of functionalized trans-imidazolines as potent inhibitors of interleukin-6 production. Bioorganic & Medicinal Chemistry, 2009, 17, 3093-3103. https://doi.org/10.1016/j.bmc.2009.03.002
    Hupp, Christopher D.; Tepe, Jetze J., Total synthesis of a marine alkaloid from the Tunicate Dendrodoa grossularia. Organic Letters, 2008, 10, 3737-3739. https://doi.org/10.1021/ol801375k
    Mosey, Robert A.; Fisk, Jason S.; Friebe, Timothy L.; Tepe, Jetze J., Synthesis of tert-Alkyl Amino Hydroxy Carboxylic Esters via an Intermolecular Ene-type Reaction of Oxazolones and Enol Ethers. Organic Letters, 2008, 10, 825-828. https://doi.org/10.1021/ol702941f
    Palumbo, Amanda M.; Tepe, Jetze J.; Reid, Gavin E., Mechanistic Insights into the Multistage Gas-Phase Fragmentation Behavior of Phosphoserine- and Phosphothreonine-Containing Peptides. Journal of Proteomic Research 2008, 7, 771-779. https://doi.org/10.1021/pr0705136
    Mosey, Robert A.; Tepe, Jetze J., Stereocontrolled synthesis of quaternary substituted amino acids using oxazolones. Tetrahedron Asymmetry, 2008, 19, 2755-2762. https://doi.org/10.1016/j.tetasy.2008.11.033
    Sharma, Vasudha; Hupp, Christopher D.; Tepe, Jetze J., Enhancing the efficacy of chemotherapeutic drugs by small molecule inhibition of NF-kappaB and checkpoint kinases. Current Medicinal Chemistry 2007, 14, 1061-1074. https://www.eurekaselect.com/article/3954
    Fisk, Jason S.; Tepe, Jetze J., Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers. Journal of the American Chemical Society 2007, 129, 3058-3059. https://doi.org/10.1021/ja0627904
    Fisk, Jason S.; Mosey, Robert A.; Tepe, Jetze J., The Diverse Chemistry of Azlactones. Chemistry Society Reviews 2007, 36, 1432-1440. https://doi.org/10.1039/B511113G
    Sharma, Vasudha; Peddibhotla, Satyamaheshwar; Tepe, Jetze J., Sensitization of Cancer Cells to DNA Damaging Agents by Imidazolines. Journal of the American Chemical Society. 2006, 128, 9137-9143. https://doi.org/10.1021/ja060273f
    Sharma, Vasudha; Tepe, Jetze J., Diastereochemical Diversity of Imidazoline Scaffolds via Substrate Controlled TMSCl Mediated Cycloaddition of Azlactones. Organic Letters, 2005, 7, 5091-5094. https://doi.org/10.1021/ol052118w
    Keni, Manasi; Tepe, Jetze J., One-pot Friedel-Crafts/Robinson-Gabriel Synthesis of Oxazoles Using Oxazolone Templates. Journal of Organic Chemistry 2005, 70, 4211-4213. https://doi.org/10.1021/jo0501590
    Peddibhotla, Satyamaheshwar; Tepe, Jetze J., Stereoselective Synthesis of Highly Substituted 1-Pyrrolines: Exo Selective 1,3- Dipolar Cycloaddition Reactions with Azlactones. Journal of the American Chemical Society 2004, 126, 12776-12777. https://doi.org/10.1021/ja046149i
    Sharma, Vasudha; Tepe, Jetze J., Potent Inhibition of Checkpoint Kinase Activity by a Hymenialdisine-derived Indoloazepine. Bioorganic & Medicinal Chemistry Letters. 2004, 14, 4319-4321. https://doi.org/10.1016/j.bmcl.2004.05.079
    Sharma, Vasudha; Lansdell, Theresa A.; Peddibhotla, Satyamaheshwar; Tepe, Jetze J., Sensitization of Tumor Cells towards Chemotherapy: Enhancing the Efficacy of Camptothecin by Novel Imidazolines. Chemistry & Biology 2004, 11, 1689-1699. https://doi.org/10.1016/j.chembiol.2004.10.006
    Sharma, Vasudha; Lansdell, Theresa A.; Jin, Guangyi; Tepe, Jetze J., Inhibition of Cytokine Production by Hymenialdisine Derivatives. Journal of Medicinal Chemistry 2004, 47, 3700-3703. https://doi.org/10.1021/jm040013d
    Peddibhotla, S.; Tepe, J. J., Multicomponent Synthesis of Highly Substituted Imidazolines via a Silicon Mediated 1,3-Dipolar Cycloaddition. Synthesis 2003, 9, 1433-1440. https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2003-40196
    Lansdell, Theresa A.; Tepe, Jetze J., Isolation of Phosphopeptides using Solid Phase Enrichment. Tetrahedron Letters 2004, 45, 91-93. https://doi.org/10.1016/j.tetlet.2003.10.111
    Peddibhotla, Satyamaheshwar; Cheng, Zigang; DellaPenna, Dean; Tepe, Jetze J., Efficient Two-step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin E. Tetrahedron Letters 2003, 44, 237-239. https://doi.org/10.1016/S0040-4039(02)02564-9
    Peddibhotla, Satymaheshwar; Jayakumar, S.; Tepe, Jetze J., Highly Diastereoselective Multicomponent Synthesis of Unsymmetrical Imidazoline Scaffolds. Organic Letters 2002, 4, 3533-3535. https://doi.org/10.1021/ol026703y
    Tepe, Jetze J. Kosogof, Christi, and Williams, Robert M., DNA Interstrand Cross-link Formation by Reductive Activation of Dehydropyrrolizidine Progenitors, Tetrahedron 2002, 58, 3553-3559. https://doi.org/10.1016/S0040-4020(02)00311-3
    Anderson, Kevin W.; Tepe, Jetze J., First Intermolecular Friedel-Crafts Acylations with -Lactams. Organic Letters 2002, 4, 459-461. https://doi.org/10.1021/ol010291w
    Anderson, Kevin W.; Tepe, Jetze J., Trifluorosulfonic Acid Catalyzed Friedel-Crafts Acylation of Aromatics with -Lactams. Tetrahedron, 2002, 58, 8475-8481. https://doi.org/10.1016/S0040-4020(02)01026-8
    Beckenbauer, Louis, Tepe, Jetze J., Eastman, R.A. Mixter, P., Williams, Robert. M and Reeves, Raymond, Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome, Chemistry & Biology 2002, 9, 427-441. https://www.cell.com/cell-chemical-biology/pdf/S1074-5521(02)00122-9.pdf
    Kosogof, Christi, Tepe, Jetze J. and Williams, Robert M, DNA Cross-linking by a Phototriggered Pyrrolic Progenitor developed from Monocrotaline, Tetrahedron Letters 2001, 42, 6641-6643. https://doi.org/10.1016/S0040-4039(01)01341-7
    Beckenbauer, Louis, Tepe, Jetze J. JCullison, J., Reeves, Raymond and Williams, Robert M., FR900482 Class of Anti-Tumor Drugs Cross-links Oncoprotein HMG I/Y to DNA in vivo, Chemistry & Biology 2000, 7, 805-812. https://doi.org/10.1016/S1074-5521(00)00028-4
    Macdonald, Timothy L., Labroli, Marc. A, and Tepe, Jetze J., DNA Topoisomerase II Inhibitors, In: Comprehensive Natural Products Chemistry, 1999, 593-614.
    Tepe, Jetze J. and Williams, Robert M., Reductive Activation of a Hydroxylamino Hemi-acetal Derivative of Dehydromonocrotaline. DNA Cross-linking Studies, Angewandte Chemie Int. Ed. 1999, 38,3501-3503. https://doi.org/10.1002/(SICI)1521-3773(19991203)38:23%3C3501::AID-ANIE3501%3E3.0.CO;2-W
    Tepe, Jetze J. and Williams, Robert M., DNA Cross-linking of a Photoactivated Dehydro- monocrotaline Progenitor, Journal of the American Chemical Society 1999, 224, 2450-2456. https://doi.org/10.1021/ja983894k
    Madalengoitia, Jose, S., Tepe, Jetze J., Werbovetz, Karl W., Lehnert, Eric K. and Macdonald, Timothy L., “Structure-Activity Relationship for DNA Topoisomerase II Induced DNA Cleavage by Azatoxin Analogs”, Bioorganic & Medicinal Chemistry 1997, 5, 1807-1815. https://doi.org/10.1016/S0968-0896(97)00113-2
    Tepe, Jetze J., Madalengoitia, Jose S., Miller Slunt, Kelly, Werbovetz, Karl. W., Grant Spoors, Peter and Macdonald, Timothy L., Inhibition of DNA Topoisomerase II by Aza-elliptitoxins Functionalyzed in the Variable Substituent Domain, Journal of Medicinal Chemistry 1996, 39, 2188-2196. https://doi.org/10.1021/jm9508806
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