University of Virginia
College of Arts & Sciences
The Tepe Lab
Our Research
The Tepe Lab moved to the University of Virginia in January 2024, from Michigan State University. Our group is made up of highly skilled and diverse people from all over the world. We specialize in synthetic organic chemistry, medicinal chemistry, and chemical biology. The group’s focus is on studying protein degradation systems and developing small molecules to alter them. We also create novel ways to synthesize natural products and their derivatives as possible therapeutic leads. Our overall goal is to develop new therapies for cancer and neurodegenerative diseases.
Recent Publications
Total Synthesis of Nagelamide W
Journal of Organic Chemistry
Dare E. George and Jetze J. Tepe*
Accessing Highly Oxidized Imidazolidinone Cores via a Curtius Rearrangement: Total Synthesis of Colensolide A
Organic Letters
Evan Savelson and Jetze J. Tepe*
Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators
ACS Omega
Sophia D. Staerz, Erika M. Lisabeth, Evert Njomen, Thomas S. Dexheimer, Richard R. Neubig, and Jetze J. Tepe*
Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection
ACS Chemical Neuroscience
Allison S. Vanecek, Jelena Mojsilovic-Petrovic, Robert G. Kalb*, and Jetze J. Tepe*
Latest News & Events
April 19, 2024
Kyra had her paper accepted for publication by Natural Products Reviews! Look out for "Advances in the Total Synthesis of Bis- and Tris-Indole Alkaloids Containing N-Heterocyclic Linker Moieties." Congrats Kyra!
April 18, 2024
Konika had a great time at the Merck Emerging Talent Symposium! We're so proud of her for getting chosen for this amazing event!
April 9, 2024
Congrats to Kyra for successfully passing her master's thesis defense! We're so proud of her and cannot wait to see what she does next!
February 25, 2024
Happy birthday Evan!
February 13, 2024
Konika and Charles both had a great time attending and presenting at the Memorial Sloan Kettering (MSK) Cancer Center diversity event!